The ISPOR RWE Summit 2023 will lead attendees behind the scenes to delve into key issues of real-world evidence (RWE) in regulatory decision-making and health technology assessment. This scientifically rigorous program will revolve around the theme of data quality and applicability, and will conduct in-depth research to demonstrate the utilization and effectiveness of RWE in medical decision-making. The specific topics will include the development, validation, applicability determination, research tools and transparency of data quality frameworks, as well as analytical issues that affect decision-making.